Although pathogens are threats to public health as causative agents of infectious diseases, a recent trend is emerging where "pathogen resources" are being recognized as important elements for enabling research and development in the biotechnology industry. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) is a method of measuring the constituent material based on the time it takes to ionize and reach the detector in a vacuum tube. Up to now, 100 proteome-based MS profiles has been obtained using MALDI-TOF MS, producing a database of clinical isolate pathogen resources in Korea. It is expected that this project will contribute to the improvement in the identification rate through continual addition to a proteome-based database.